Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge

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Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge

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NCBI - The National Center for Biotechnology Information
Published online 2021 Aug 3
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19
Abstract:
In 2015, the Nobel Committee for Physiology or Medicine, in its only award for treatments of infectious diseases since six decades prior, honoured the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world’s most devastating tropical diseases. Since March 2020, when IVM was first used against a new global scourge, COVID-19, more than 20 randomized clinical trials (RCTs) have tracked such inpatient and outpatient treatments. Six of seven meta-analyses of IVM treatment RCTs reporting in 2021 found notable reductions in COVID-19 fatalities, with a mean 31% relative risk of mortality vs. controls. During mass IVM treatments in Peru, excess deaths fell by a mean of 74% over 30 days in its ten states with the most extensive treatments. Reductions in deaths correlated with the extent of IVM distributions in all 25 states with p < 0.002. Sharp reductions in morbidity using IVM were also observed in two animal models, of SARS-CoV-2 and a related betacoronavirus. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, possibly yielding full efficacy against emerging viral mutant strains
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383101/
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Ivermectin use in India and Worldwide - Ivermectin obliterates 97 percent of Delhi cases

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Ivermectin use in India and Worldwide
June 27, 2021

Ivermectin obliterates 97 percent of Delhi cases

By Justus R. Hope, MD Jun 1, 2021 Updated Jun 7, 2021


A 97% decline in Delhi cases with Ivermectin is decisive - period. It represents the last word in an epic struggle to save lives and preserve human rights. This graph symbolizes the victory of reason over corruption, good over evil, and right over wrong. It is as significant as David’s victory over Goliath. It is an absolute vindication of Ivermectin and early outpatient treatment. It is a clear refutation of the WHO, FDA, NIH, and CDC's policies of "wait at home until you turn blue" before you get treatment.

Dr. Pierre Kory told the world on December 8, 2020, that Ivermectin "obliterates" this virus. Obliterate means to decimate, demolish, or annihilate. It means to eliminate or destroy all trace, indication, or significance.

This graph shows that Ivermectin, used in Delhi beginning April 20, obliterated their COVID crisis. No one should be able to talk you out of this - not a salesman, a drug company, a television celebrity doc, and certainly not the top doctor for the WHO or the NIH who is paid to do that.

Will you believe this 97% eradication graph, or will you believe the propaganda pitched by the Big Media, Big Pharma, the WHO, and the FDA, who share massive financial conflicts of interest – those who say there is insufficient evidence?

What evidence could be any clearer than a 97% reduction in five weeks? That number is better than the current vaccines and beyond the reach of most medicines.

The WHO cautioned India they were making a mistake by using Ivermectin. They told them it could be dangerous, that there was no evidence it worked. How many lies will you buy before you stand up for the truth?

The fatal mistake would have been to NOT use Ivermectin.

Mercifully they used it, and they saved Delhi. But tragically, Tamil Nadu did not, and their state was devastated. Their new cases rose from 10,986 to 36,184 – a tripling.

No one can hide that. Their refusal to use Ivermectin harmed them. Not only did Tamil Nadu's cases rise to the highest in India, but their deaths skyrocketed from 48 on April 20 to 474 on May 27 – a rise of ten-fold.

Meanwhile, Delhi's deaths IN THE SAME PERIOD fell from 277 to 117. So which advice would you have wanted your state to follow?

In America, Baylor’s Dr. Peter McCullough, Yale’s Dr. Harvey Risch, and Harvard’s Dr. George Fareed first advised early outpatient treatment in testimony to the US Senate on November 19, 2020. Dr. McCullough and his colleagues were the first in the world to publish an early outpatient treatment protocol for COVID-19.

https://www.amjmed.com/article/S0002-93 ... 2/fulltext

That protocol has since been revised by Dr. George Fareed and his dynamic associate, Dr. Brian Tyson. They have now saved 6,000 COVID patients in California’s Imperial Valley.

https://www.thedesertreview.com/health/ ... e98c3.html

Less than one month later, Dr. Pierre Kory sounded the alarm for a second time on December 8, 2020, to the US Senate. He advised the use of Ivermectin, yet no one listened. No Ivermectin guidelines were instituted. On December 8, the US suffered 2,821 COVID deaths. With Ivermectin, cases could have been quickly crushed. Fatalities would have dropped in short order, as the example of Delhi shows us.

But instead, the United States followed the WHO and FDA’s official advice and waited for the vaccines. They sat on their hands while people gasped. They watched and did nothing as millions turned blue and flooded the hospitals - no Ivermectin approval. So like Tamil Nadu, our US cases and deaths also skyrocketed.

By January 8, just four weeks later, US daily cases had risen from 219,000 to 300,000, and deaths were up from 2,821 to 3,895. Even more Americans were to die due to this failed health policy of ignoring Ivermectin and early outpatient treatment.

Delhi did it right. The United States and Tamil Nadu did it wrong. It cost half a million precious lives and horrific pain and suffering for the world. The pandemic was prolonged for no good reason.

Now we are in a different position. We as a people have absolute evidence of Ivermectin’s efficacy. In Delhi, we heard not one single story of Ivermectin being toxic or causing any difficulty. On the contrary, it is safe, and it saved tens of thousands from COVID.

But more immediately, what can we do now? What will you do as a concerned citizen to get the word out? What can you do to save your fellow human beings from repeating these costly errors? Start with sharing the book, Ivermectin for the World, with your church, your minister, and all your social contacts. Then, spread the word far and wide:

People can safely take Ivermectin to prevent and treat COVID-19.

The rest of the world must hear about Ivermectin as new areas experience similar surges. A new hybrid variant is brewing in Vietnam. Notify them! They need to know there is more than masks and social distancing. There is more than waiting for vaccines. Ivermectin is effective against ALL the variants. The vaccines ARE NOT.

But, unfortunately, the authorities will continue to censor this information; thus, the responsibility of getting the word out rests squarely upon the citizens of the planet, you and me.

https://www.amazon.com/Ivermectin-World ... B0943T564G

Lead a peaceful protest. Share this article with everyone you know, your social media, your email contacts, relatives, friends, and co-workers. You may think that none of this applies to you because you have already been vaccinated. That is unfortunately not true.

Listen to Dr. Peter McCullough on this subject. He is the Vice-Chair of Medicine at Baylor University Medical Center in Dallas, Texas. He is among the most published cardiologists in the world. He is arguably the most courageous physician to speak out.

https://vimeo.com/553518199

No one deserves COVID. No one deserves to die when we have effective treatment.

Do you continue to believe the pronouncements of those agencies that have failed you so many times before? Those agencies who have told the media to give you only filtered information, those agencies who have ignored the world's leading scientists.

Take a look at this graph. Delhi was in dire straits on April 20 with 28,395 new daily COVID-19 cases and rising.

We sounded the alarm. The All India Institute for Medical Science (AIIMS) and the Indian Council of Medical Research (ICMR) had the guts to listen. They listened to the 56 studies involving 18,447 patients showing up to a 91% reduction in death with Ivermectin. They listened to scientists like Dr. Pierre Kory and the FLCCC. They listened to world-class experts like Dr. Tess Lawrie of the BIRD group and Dr. Peter McCullough of the C19 group. They were smart.

The book Ivermectin for the World was released May 1, 2021, and called for the urgent adoption of Ivermectin by India on a humanitarian basis to save lives. "What we could not do for America, we can do for India!" was our mantra.

And we did! This is what happened to cases in the areas that chose Ivermectin:

Delhi : ¯ 97% [28,395 to 956]

Uttar Pradesh: ¯ 95% [37,944 to 2,014]

Goa: ¯ 85% [4195 to 645]

Karnataka: ¯ 60% [50,112 to 20,378]

Uttarakhand: ¯ 87% [9,642 to 1,226]

Observe what happened to those areas that DID NOT choose Ivermectin:

Tamil Nadu ­ 173% [10,986 to 30,016]

Odisha ­ 50% [4,761 to 7,148]

Assam ­ 240% [1,651 to 5,613]

Arunachal Pradesh ­ 656% [ 61 to 461]

Tripura ­ 828% [92 to 854]

On May 3, the FLCCC and the BIRD groups issued a press release and called for the immediate global use of Ivermectin for COVID-19. On May 7, Dr. Paul Marik, the second most published Intensive Care Specialist in the world and founding member of the FLCCC, did the same. He added that we could no longer trust “larger health authorities to make an honest examination of the medical and scientific evidence.”

https://eurekalert.org/pub_releases/202 ... 050621.php

In India, the acid test was to compare the fates of those Indian areas that adopted the drug versus those that did not. This would be the ultimate natural experiment. Finally, the plain truth would be revealed to all the world. It was no longer the special interests, Big Pharma, Big Regulators, and Big Media, who had been censoring, swindling, and conniving. Now the fight would be fair because all the money in the world could not conceal the cases in Delhi. The world had a front-row seat to witness these results. And it bears repeating; the results are in.

Delhi’s cases are down 97% from 28,395 on April 20 to just 956 on May 29.

So the question now is this: Are you going to believe the obvious contained in these graphs? Or are you going to believe those corrupt agencies that do not have your best interests at heart, those who have lied to you many times before?

I suggest you believe the scientists from non-profit groups like FLCCC and BIRD who have nothing to gain except saving your life. They are the most trustworthy. You can support Dr. Tess Lawrie’s charitable work at:

https://www.gofundme.com/f/help-us-get- ... or-covid19

You can support Dr. Pierre Kory’s charitable work on:

https://covid19criticalcare.com/

You can support Dr. George Fareed’s charitable work and his COVID-19 project by contributing to www.holtvillebaptist.com in the name of the COVID-19 Fareed Project. Dr. George Fareed is a voice of wisdom.

https://youtu.be/czJuCCBIoX4

Dr. Fareed is a former NIH scientist and Harvard Professor. He holds patents on three cancer drugs. He was named the 2015 California Rural Physician of the Year, and he won the Plessner Memorial Award given by the California Medical Association for his ethics and clinical excellence. So, you can trust and believe Dr. Fareed.

https://youtu.be/7pKBfRHFJAg

The choice is clear. Ivermectin is the safe, repurposed Nobel Prize-Winning drug that effectively reduces death up to 91% from COVID-19. It does not produce blood clots, heart attacks, or strokes. It does not cause violent immune reactions. And it reduced the COVID-19 cases in Delhi, India, by an astonishing 97% in five weeks. It costs pennies.

Tell the poor citizens of Tamil Nadu who are still in the dark and remain forbidden from using it. Tell the rest of the world. Show your doctor the studies. They are updated daily on www.ivmmeta.com. If your doctor refuses, find another doctor.

Listen to scientists and physicians who are driven by their Hippocratic Oaths to do what is right, not the doctors who are paid vast sums of money by lucrative interests to tow the party line.

So the next time you hear a highly paid doctor advising you that Ivermectin does not work, or you read another article disputing this, please believe your eyes and this graph.

Use your common sense. Some truths are self-evident, and Ivermectin's pronounced effect against this virus is one of them. Another self-evident truth, straight from the Declaration of Independence, is the human right to life - which includes the right to select medical treatment - free from governmental interference.

We do not require scientists to interpret these fundamental truths. We do not need a philosopher to know that censorship of life-saving information is wrong. We do not require any more "studies" to understand that all the world needs Ivermectin - immediately.

“What we did for India, we must now do for the rest of the world.


https://covid.us.org/2021/06/27/ivermec ... -in-india/
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Re: Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global sco

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The Story Of Ivermectin And COVID-19

https://rumble.com/vlzihf-the-story-of- ... id-19.html
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What Countries are Using Ivermectin?

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What Countries are Using Ivermectin?
August 26, 2021
Ivermectin is currently used for about 23% of the world's population. Countries where COVID-19 mortality is close to zero may not have incentive to adopt treatments. When excluding these countries, ivermectin adoption is about 30%. We excluded countries where the cumulative mortality over the preceding month was less than 1 in 1 million, according to the data at https://ourworldindata.org/). For the estimated population coverage, isolated use, some regions, mixed usage, and many regions use a factor of 0.05, 0.25, 0.5, and 0.75 respectively.

What Countries are Using Ivermectin



https://www.onedaymd.com/2021/08/what-c ... ectin.html
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Don’t mention Ivermectin; it’ll upset the vaccine rollout

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Don’t mention Ivermectin; it’ll upset the vaccine rollout
12th May 2021 by Editor
By Andrew Bannister*

What if there was a cheap drug, so old its patent had expired, so safe that it’s on the WHO’s lists of Essential and Children’s Medicines, and used in mass drug administration rollouts? What if it can be taken at home with the first signs COVID symptoms, given to those in close contact, and significantly reduce COVID disease progression and cases, and far fewer few people would need hospitalisation?

The international vaccine rollout under Emergency Use Authorisation (EUA) would legally have to be halted. For an EUA to be legal, “there must be no adequate, approved and available alternative to the candidate product for diagnosing, preventing or treating the disease or condition.” The vaccines would only become legal once they passed level 4 trials and that certainly won’t happen in 2021.

This would present a major headache for the big public health agencies led by the WHO. The vaccine rollout, outside of trials, would become illegal. The vaccine manufactures, having spent hundreds of million dollars developing and testing vaccines during a pandemic, would not see the $100bn they were expecting in 2021. In a pandemic, and for the next one, we need big pharma to react quickly, and the best way to that, is to reward them financially. Allowing any existing drug, at this time, well into stage 3 trials, to challenge the legality of the EUA of vaccines, is not going to happen easily. On the 31st of March 2021, the WHO recommended against the use of Ivermectin for COVID treatment, citing safety and lack of large RCT proof.

The question of why the WHO would do this is difficult to answer, only if you ignore the importance of the legality of the EUA, and the time tested advice, of following the money. The WHO, a once noble organisation funded by the worlds countries, now receives less than 20% of its budget from member states. The Bill and Melinda Gates Foundation is the second biggest sponsor after the USA. The GAVI Alliance, a private/public organisation promoting vaccines, was founded by Gates, and now pushing for vaccine passports, are the 4th biggest sponsor to WHO. Tedros Adhanom Ghebreyesus, the WHO Director-General, served on the GAVI board for several years. The WHO, in 2021 changed the definition of “herd immunity”, to occurring only when the global population has been vaccinated.

The WHO has either made serious mistakes in their analysis or deliberately undermined Ivermectin and other early treatment drugs, in favour of vaccinating the world. Obviously this is a huge windfall for vaccine manufacturers, with Pfizer set to receive over a trillion rand from vaccines over the next five years according to Morgan Stanley.

In January this year, the several months long, Ivermectin research, meta-analysis of Randomised Control Trials (RCT), commissioned by WHO was released. The paper showed that Ivermectin reduces death by 74% and is 85% effective as prophylaxis. The trial leader, Dr Andrew Hill, was on Zoom meetings saying that governments should secure their source before demand outstrips supply and that it would be immoral, not to roll it out. The same month, two other independent, unsponsored meta-analysis confirmed a similar range of effectiveness at various stages of the disease. While effective at all stages of the disease, Ivermectin is most effective as a prophylaxis and about 80% in early treatment, depending on dose used.

The WHO currently have no advice or recommendation’s for early treatment apart from recommending against self-medication. If you don’t heal in the first week, when symptoms are generally mild, by the time you have to go to the hospital with breathing problems, your chances of dying have increased significantly. The use of Ivermectin and other repurposed drugs, could prevent that. As its safer than paracetamol, it should be available over the counter. As is happening in Mexico City and some states in India, anyone testing positive or feeling sick should take it, and give it to those they are in close contact with. It may be possible, if you want to attend a large social event or travel in a plane, that you take a pill, four hours before, and you will have significant protection for a few days. Lockdowns could end.

Ivermectin has been used in humans for 35 years and over 4 billion doses have been administered. Merck, the original patent holder, donated 3.7 billion doses to developing countries. 2015 the two individuals who developed Ivermectin were awarded a Nobel Prize for medicine. While known primarily as an anti-parasitic, Ivermectin has powerful anti-viral and anti-inflammatory properties. Its safety is documented at doses twenty times the normal. Only 19 deaths are known and side-affects are generally mild and short. As a comparison, approximately 450 US citizens die from paracetamol every year.

Merck’s patent on Ivermectin expired in 1996 and they produce less than 5% of global supply. In 2020 they were asked to assist in Nigerian and Japanese trials but declined both. In 2021 Merck released a statement claiming that Ivermectin was not an effective treatment against Covid-19 and bizarrely claimed, “A concerning lack of safety data in the majority of studies” of the a drug they donated to be distributed in mass rollouts, by primary care workers, in mass campaigns, to millions in developing countries. The media reported the Merck statement as a blinding truth without looking at the conflict of interests when days later, Merck received $356m from the US government to develop an investigational therapeutic. The WHO even quoted Merck, as evidence, that it didn’t work, in their recommendation against the use of Ivermectin. It’s a dangerous world when corporate marketing determines public health policy. Global vaccine rollout, to everyone, is the policy.

The vaccine rollout is worth about $100bn in 2021, and there may well be annual updates to deal with new variants of COVID. The WHO answers to nobody but its’ funders. Less than 20% of its budget comes member states, the bulk coming from other sources. The Bill and Melinda Gates Foundation is the second largest sponsor of the organisation. GAVI, a vaccine alliance, founded by Gates and WHO Director General Tedros Ghebreyesus, served on its board prior to his current position, is the fifth largest contributor.

In March 2021, WHO said that Ivermectin was not recommend for the treatment of COVID outside of trials. They did this by ignoring their own months long, in-depth investigation by Dr Andrew Hill, that found Ivermectin was associated with 74% reduction in fatalities, and replaced it with a hastily done analysis that cherry picked from five, seven or sixteen trials (the report contradicts itself) but only cite 5 trails. The figures ,the WHO report supplies, show a reduction of death by 81%, but with a “very low certainty of evidence”. The WHO report didn’t even mention prophylaxis, where Ivermectin’s most effective, saying that fell outside its mandate. The WHO will not approve Ivermectin’s use, without it first proving itself in a large RCT. These trials cost millions and nobody, except those with a financial interest in vaccines, have offered to fund. The WHO are best placed to run large RCT’s on existing drugs, but haven’t done so with Ivermectin, despite it being over a year, since Ivermectin was proved to kill COVID in a lab. As only big pharma can afford the large RCT, the only drugs that go through the large RCT’s, are the new ones developed by big pharma, and become the only ones approved by WHO.

Almost every media house around the world has contributed to the marginalisation of Ivermectin. No mainstream journalists have investigated the evidence or questioned and debated scientists supporting it. It’s called an “animal drug” and dangerous. Ivermectin is seen as a repeat of hydroxychloroquine and not to be taken seriously. Belief in it, worthy only of derision.

On 10 December 2020, at the World Press Freedom Conference, an extension to the Trusted News Initiative (TNI) was announced. Founded to prevent false information around elections, the TNI, whose members are leading media houses: AP, AFP, BBC, CBC, European broadcast Union, Facebook, Financial Times, First Draft, Google, YouTube, The Hindu, Microsoft, Reuters, Twitter and Washington Post, were now extending that to vaccines. In a surprisingly underreported event, many of the world’s biggest media, agreed to promote the global vaccine rollout and focus on combatting the spread of harmful vaccine disinformation. While noble and well-intended, this has unfortunately led to a media silence on promising, early treatments that could significantly drop hospitalisations.

The March this year, New York Times broke a story, repeated around the world, reporting a trial that proved “Ivermectin had no effect”. The Lopez-Medina trial, published in JAMA, a leading medical journal, was held as the gold standard for Ivermectin RCT’s. In the trial, reminiscent of a “big tobacco” hit-job, vaccine manufactures paid the researchers (documented in the papers Conflicts Of Interests section). There are many faults in the trial. Among them, they accidentally gave Ivermectin to both arms of the trial and changed the trials primary outcome, mid-trial, three times. Normally, nobody would pay a trial any attention after these significant problems. As the trial was on a young heathy population, in an area with high Ivermectin use, freely available from the mayor during their first COVID wave, you were allowed on the trial if you hadn’t taken Ivermectin for 5 days, despite it’s effects being noticeable up to a month after a single dose. Surprisingly less than 3% of the participants had disease progression, against an expectation of 18%. The rare but specific Ivermectin side effect, blurred vision, was within 0,3% (11.3/11.6%) of both groups as were other side effects. The results were collected telephonically and no physical examination was done. From their result, with surprisingly few people having disease progression (some suggest that the trial inadvertently proves Ivermectin’s efficiency), it’s not possible to arrive at the conclusion that Ivermectin doesn’t work, which is what they did, and the media bought it.

Unless you know where to look, you will find hardly any positive information on Ivermectin. Social media makes it very difficult to say anything positive about it without the poster getting blocked from the platforms for lengthy periods. YouTube has made the promotion of Ivermectin, a violation of its policies. There is no public conversation in the media about it. It’s just ignored. Respectable medical journals are sitting with piles of Ivermectin papers on their desks that they refuse to publish without providing reason, despite at least one of them having passed peer review by two FDA reviewers. The book “Manufacturing of Consent” comes to mind where Chomsky and Herman look at how mass media serves the rich. It’s a David against Goliath fight, a cheap generic vs Big Pharma.

There are now 27 RCT’s, about 7 meta -analysis and many observational trials, that show Ivermectin works. There is very little evidence that it doesn’t work. The WHO were very sparse in detail and process, in their recommendation against its use. New research from the All India Institute of Medical Science (AIIMS), on a group of over 3500 health care workers, using two doses of Ivermectin as prophylactic, reduced cases among health care workers by 83% in the following month. Mexico City has for several months been using a test and treat with Ivermectin strategy. A research paper by Mexico City Health, claims that, depending on dosing, they have reduced hospitalisations by 56-73%. India in its current destructive wave, has just taken the example set by its two most successful states, and authorised the use of Ivermectin in early treatment. Doctors who use it, swear by it. As for more proof, the Gates/Together trial is ongoing, but given Gates’s large investments in vaccines, its results, already mistrusted. In Goa they have just authorised giving Ivermectin to everyone who tests, not waiting for a result. If Ivermectin works, it should soon be clearly seen unless the “Ivermectin is dangerous” group wins. We need more studies, especially on higher dosing, but we know it’s safe, so no need to wait.

Ultimately what this means, is that if Ivermectin and other repurposed drugs (like the promising anti-depressant Fluvoxamine), work for early treatment, you won’t have to use a vaccine, that’s still in trial, with unknown long-term safety or ability to treat future variants, and for which, the manufactures accept no liability.

In case you get sick, keep Ivermectin close by for early, household treatment, and you will prevent viral replication early and almost certainly, avoid hospital. You would have also built an immune response that will provide natural protection against future infections. Its wide-spread use, should dampen waves of disease, while vaccines can use this time to prove themselves, with long term safety and efficiency.

Andrew Bannister says “I can provide proof for everything I have written” and was last published 30 years ago in the medical journal Lancet.
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